| Autor: |
Serra Kamer, Sunde Yilmaz Susluer, Tugce Balci Okcanoglu, Cagla Kayabasi, Besra Ozmen Yelken, Sinan Hoca, Emin Tavlayan, Nezahat Olacak, Yavuz Anacak, Murat Olukman, Cumhur Gunduz |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Cancer Medicine, Vol 12, Iss 19, Pp 19874-19888 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2045-7634 |
| DOI: |
10.1002/cam4.6593 |
| Popis: |
Abstract Background The optimal radiobiological model, which assesses the biological effects of novel radiotherapy techniques that concurrently modify multiple physical factors, has not yet been defined. This study aimed to investigate the impact of intensity‐modulated radiotherapy (IMRT) and volumetric‐modulated arc therapy (VMAT) on cellular response in head and neck cancer and melanoma models. Methods Clonogenic analysis, DNA double‐strand break analysis, apoptosis, and cell cycle analysis were performed on cancer stem cell models, cancer models, and normal tissue cell models to assess radiation sensitivity. Results The segmented radiation approach used in IMRT applications enhanced radiosensitivity and cytotoxicity in the cancer models, while changes in dose rate had varying effects on cytotoxicity depending on the tumor cell type. VMAT increased cellular resistance, favoring treatment outcomes. Conclusions The biological processes were influenced differently by dose rate, IMRT, and VMAT depending on the tumor cell type. The selection of the most appropriate technique is crucial in representing new radiotherapy approaches. The obtained data can serve as a model to address clinical questions in daily practice. The integration of non‐standard outcomes with standard applications should be considered in clinical settings. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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