Is oxidative stress associated with activation and pathogenesis of inflammatory bowel disease?
| Autor: | Yuksel Mahmut, Ates Ihsan, Kaplan Mustafa, Fettah-Arikan Mehmet, Ozderin-Ozin Yasemin, Yalin-Kilic Zeki Mesut, Topcuoglu Canan, Kayacetin Ertugrul |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Journal of Medical Biochemistry, Vol 36, Iss 4, Pp 341-348 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1452-8258 1452-8266 |
| Popis: | Background: We aimed to determine the levels of total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) and paraoxonase1/arylesterase levels in inflammatory bowel disease (IBD), and the relation between these molecules and the activity index of the disease. Methods: Eighty IBD patients (ulcerative colitis (UC)/Crohn disease (CD) 40/40) and 80 control group participants were included in the study. Oxidative stress parameters were measured using the colorimetric method. As disease activity indexes, the endoscopic activity index (EAI) was used for UC and the CD activity index (CDAI) was used for CD. Results: In IBD patients, mean TAS (1.3± 0.2 vs 1.9± 0.2, respectively; p < 0.001) and arylesterase (963.9± 232.2 vs 1252.9± 275, respectively; p < 0.001) levels were found to be lower and TOS level (5.6± 1.6 vs 4 .0 ± 1 .0 , respectively; p < 0.001) and OSI rate (4.5± 1.6 vs 2 .2± 0.8, respectively; p < 0.001) were found to be higher compared to the control group. A strong positive correlation was found between EAI and TOS levels (r = 0.948, p < 0.001) and OSI rate (r = 0.894, p < 0.001) for UC patients. A very strong positive correlation was found between EAI and TOS levels (r = 0.964, p < 0.001) and OSI rate (r = 0.917, p |
| Databáze: | Directory of Open Access Journals |
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