| Autor: |
Federica Piani, Fumihiko Sasai, Petter Bjornstad, Claudio Borghi, Ashio Yoshimura, Laura G. Sanchez-Lozada, Carlos Roncal-Jimenez, Gabriela E. Garcia, Ana Andres Hernando, Gabriel Cara Fuentes, Bernardo Rodriguez-Iturbe, Miguel A Lanaspa, Richard J Johnson |
| Jazyk: |
English<br />Portuguese |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Brazilian Journal of Nephrology, Vol 43, Iss 4, Pp 572-579 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2175-8239 |
| DOI: |
10.1590/2175-8239-jbn-2020-u002 |
| Popis: |
Abstract Hyperuricemia is common in chronic kidney disease (CKD) and may be present in 50% of patients presenting for dialysis. Hyperuricemia can be secondary to impaired glomerular filtration rate (GFR) that occurs in CKD. However, hyperuricemia can also precede the development of kidney disease and predict incident CKD. Experimental studies of hyperuricemic models have found that both soluble and crystalline uric acid can cause significant kidney damage, characterized by ischemia, tubulointerstitial fibrosis, and inflammation. However, most Mendelian randomization studies failed to demonstrate a causal relationship between uric acid and CKD, and clinical trials have had variable results. Here we suggest potential explanations for the negative clinical and genetic findings, including the role of crystalline uric acid, intracellular uric acid, and xanthine oxidase activity in uric acid-mediated kidney injury. We propose future clinical trials as well as an algorithm for treatment of hyperuricemia in patients with CKD. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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