Magnetic targeting of paclitaxel-loaded poly(lactic-co-glycolic acid)-based nanoparticles for the treatment of glioblastoma

Autor: Ganipineni LP, Ucakar B, Joudiou N, Bianco J, Danhier P, Zhao M, Bastiancich C, Gallez B, Danhier F, Préat V
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: International Journal of Nanomedicine, Vol Volume 13, Pp 4509-4521 (2018)
Druh dokumentu: article
ISSN: 1178-2013
Popis: Lakshmi Pallavi Ganipineni,1 Bernard Ucakar,1 Nicolas Joudiou,2 John Bianco,1 Pierre Danhier,2 Mengnan Zhao,1 Chiara Bastiancich,1 Bernard Gallez,2 Fabienne Danhier,1,* Véronique Préat1,* 1Université catholique de Louvain, Advanced Drug Delivery and Biomaterials Research Group, Louvain Drug Research Institute, Brussels, Belgium; 2Université catholique de Louvain, Louvain Drug Research Institute, NEST Nuclear and Electron Spin Technologies Platform, Brussels, Belgium *These authors contributed equally to this work Introduction: Glioblastoma (GBM) therapy is highly challenging, as the tumors are very aggressive due to infiltration into the surrounding normal brain tissue. Even a combination of the available therapeutic regimens may not debulk the tumor completely. GBM tumors are also known for recurrence, resulting in survival rates averaging
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