Expressions of Cyr61 and WISP-3 in Non-small Cell Lung Cancer and Its Clinical Significance
| Autor: | Jianfa LV, Youcheng ZOU, Chunwei ZHANG, Zhifu MAO |
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| Jazyk: | čínština |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Chinese Journal of Lung Cancer, Vol 13, Iss 12, Pp 1122-1126 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1009-3419 1999-6187 |
| Popis: | Background and objective Cysteine-rich protein 61 (Cyr61) plays a role as a tumor suppressor in non-small cell lung cancer (NSCLC). Cyr61 and WISP-3 have a very significant sequence homology, belonging to the same CCN gene family. The aim of this study is to investigate the expressions of Cyr61 and WISP-3 in NSCLC, and explore the relationship between their expressions and tumor's clinicopathological characteristics. Methods The expressions of Cyr61 and WISP-3 were detected in 54 cases with primary NSCLC and their corresponding normal lung tissues in control group by immunohistochemical staining (SP), and the clinical data were analyzed. Results Down-regulation of Cyr61 and up-regulation of WISP-3 were both found in lung cancer tissue compared with the corresponding normal lung tissue (both P < 0.001); The expression of Cyr61 was negatively correlated with the expression of WISP-3 (r=-0.395, P=0.003); Cyr61 expression levels was closely correlated with tumor grade, tumor type, clinical stage, family history, smoking and metastasis (P < 0.05). Also, WISP-3 was closely correlated with tumor grade, clinical stage and age (P < 0.05). Conclusion The expressions of Cyr61 and/or WISP-3 may be important biological markers in reflecting the progression, biological behaviors, metastatic potential and prognosis of NSCLC. |
| Databáze: | Directory of Open Access Journals |
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