Formulation design and evaluation of Cefuroxime axetil 125 mg immediate release tablets using different concentration of sodium lauryl sulphate as solubility enhancer

Autor:	Fozia Israr, Zafar Alam Mahmood, Fouzia Hassan, Syed Muhammad Farid Hasan, Sabahat Jabeen, Shazia Naz, Lubna Bashir
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Cefuroxima axetil/comprimidos de liberação imediata/propriedades físico-mecânicas Compressão direta Lauril sulfato de sódio Pharmacy and materia medica RS1-441
Zdroj:	Brazilian Journal of Pharmaceutical Sciences, Vol 50, Iss 4, Pp 943-953 (2014)
Druh dokumentu:	article
ISSN:	2175-9790 1984-8250
DOI:	10.1590/S1984-82502014000400030
Popis:	Cefuroxime axetil immediate release tablets were formulated by direct compression method with different percentages of sodium lauryl sulphate (SLS) such as 0.5, 1.0, 1.5 and also without SLS. Resulting batches of tablets were evaluated by both pharmacopeial and non-pharmacopeial methods to ascertain the physico-mechanical properties. Dissolution test were carried out in different medium like 0.07 M HCl, distilled water, 0.1M HCl of pH 1.2 and phosphate buffers at pH 4.5 and 6.8 to observe the drug release against the respective concentration of SLS used. Later, test formulations were compared by f1(dissimilarity) and f2(similarity) factors using a reference brand of cefuroxime axetil. Significant differences (p
Databáze:	Directory of Open Access Journals
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