Selection Pressures on RNA Sequences and Structures

Autor: Katja Nowick, Maria Beatriz Walter Costa, Christian Höner zu Siederdissen, Peter F Stadler
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Evolutionary Bioinformatics, Vol 15 (2019)
Druh dokumentu: article
ISSN: 1176-9343
11769343
DOI: 10.1177/1176934319871919
Popis: With the discovery of increasingly more functional noncoding RNAs (ncRNAs), it becomes eminent to more strongly consider them as important players during species evolution. Although tests for negative selection of ncRNAs already exist since the beginning of this century, the SSS-test is the first one for also investigating positive selection. When analyzing selection in ncRNAs, it should be taken into account that selection pressures can independently act on sequence and structure. We applied the SSS-test to explore the evolution of ncRNAs in primates and identified more than 100 long noncoding RNAs (lncRNAs) that might evolve under positive selection in humans. With this test, it is now possible to more thoroughly include ncRNAs into evolutionary studies.
Databáze: Directory of Open Access Journals
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