Detection of strain types and analysis of risk factors among subjects from Hainan Province, China

Autor: Runxiang Chen, Daya Zhang, Yanting Lv, Shimei Huang, Da Li, Fan Zeng, Chen Chen, Xiaodong Zhang, Shiju Chen, Jun Wang, Feihu Bai
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of International Medical Research, Vol 52 (2024)
Druh dokumentu: article
ISSN: 1473-2300
03000605
DOI: 10.1177/03000605241253454
Popis: Objective To explore the prevalence of type I and type II Helicobacter pylori infection and investigate risk factors in a population from Hainan Province in China. Methods Data came from a large, cross-sectional study conducted from August 2022 to April 2023 involving five cities of Hainan. Subjects with confirmed 14C-urea breath test (UBT) and positive serological assay were included. All subjects had a gastroscopy. According to presence or absence of CagA/VacA proteins, subjects were classified as either type I (present) or type II strains (absent). Gastroscopic findings and several socio-demographic factors were examined for correlation with antibody serotyping. Results In total, 410 subjects were investigated for H. pylori strain types. The overall prevalence of the highly virulent, type I H. pylori strain was 79% (324/410) and type II strain was 21% (86/410). There was a strong association between type I strain and peptic ulcer disease. Of several sociodemographic factors investigated, only smoking and data over baseline (DOB) values showed significant differences between type 1 and type II strains. Logistic regression analysis showed a lower risk of type I H. pylori infection in smokers compared with non-smokers, and a higher risk of H. pylori type I infection in subjects with medium and high data over baseline (DOB) values compared with subjects who had low DOB values. Conclusion Highly virulent, type I H. pylori infections predominate in Hainan and the co-positivity of CagA and VacA antibodies are related to type I H. pylori infection. We found that Type I H. pylori was closely associated with peptic ulcer disease and the DOB values were generally high.
Databáze: Directory of Open Access Journals
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