The dynamic nature of netrin-1 and the structural basis for glycosaminoglycan fragment-induced filament formation

Autor: Markus Meier, Monika Gupta, Serife Akgül, Matthew McDougall, Thomas Imhof, Denise Nikodemus, Raphael Reuten, Aniel Moya-Torres, Vu To, Fraser Ferens, Fabian Heide, Gay Pauline Padilla-Meier, Philipp Kukura, Wenming Huang, Birgit Gerisch, Matthias Mörgelin, Kate Poole, Adam Antebi, Manuel Koch, Jörg Stetefeld
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-36692-w
Popis: In this work, the authors report that heparin oligosaccharides have a significant impact on the highly dynamic behaviour of netrin-1 by inducing hierarchical and distinct super assemblies leading to unique, yet unknown netrin-1 filament formation.
Databáze: Directory of Open Access Journals