Neuroprotective Effects of Berberine Hydrochloride on Methamphetamine-induced Cognitive Dysfunction: Immunohistochemical and Behavioral Studies in Rats
| Autor: | Leila Rezaeian, Mehdi Khaksari, Raheleh Rafaiee, Hamid Kalalian Moghaddam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Basic and Clinical Neuroscience, Vol 13, Iss 4, Pp 443-454 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2008-126X 2228-7442 |
| Popis: | Introduction: Methamphetamine (MA) as an addictive psychostimulant drug affects the central nervous system. The current research aimed to evaluate the impact of berberine hydrochloride on improving cognitive function and neuroprotective effects in rats addicted to MA. Methods: In this study, 27 male Wistar rats were randomly assigned to three groups, including control, MA addiction, and MA addiction with berberine hydrochloride (100 mg/kg/d) orally during the three weeks of withdrawal. Two groups received self-administered inhaled MA for two weeks (up to 10 mg/kg). Following the experimental procedures, a Morris water maze (MWM) and shuttle box were used to assess memory, and hippocampal sections from the animals were examined for caspase-3, Ki-67, and glial fibrillary acidic protein (GFAP) expression. Results: The obtained results from the Morris water maze (MWM) showed that berberine hydrochloride decreases (P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|