Role of Leptin/Osteopontin Axis in the Function of Eosinophils in Allergic Rhinitis with Obesity

Autor: Wenlong Liu, Qingxiang Zeng, Yanqiu Chen, Ren Zhong Luo
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Mediators of Inflammation, Vol 2018 (2018)
Druh dokumentu: article
ISSN: 0962-9351
1466-1861
DOI: 10.1155/2018/9138904
Popis: Background. Allergic rhinitis (AR) is characterized by tissue and blood eosinophilia. Previous studies showed enhanced eosinophilia in allergic rhinitis patients with obesity, suggesting an association between obesity and eosinophilia. However, the interaction and mechanism between obesity and eosinophilia is still unclear. Methods. We recruited thirty AR children and 30 controls in this study. Expression of leptin and osteopontin (OPN) proteins in serum was detected, and correlation analysis with eosinophilia was performed. The effect of leptin or OPN on eosinophil apoptosis, adhesion, migration, and activation of eosinophil was examined. Ovalbumin-sensitized mice were established to prove the role of obesity on eosinophil regulation by leptin and OPN. Results. We found that upregulated serum and nasal leptin and OPN expression in AR were positively correlated with eosinophilia and eosinophil cationic protein levels. Leptin or OPN inhibited eosinophil apoptosis, demonstrated as inhibited DNA fragmentation and phosphatidylserine (PS) redistribution (P
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