Cardiomyocyte dysfunction during the chronic phase of Chagas disease

Autor:	Danilo Roman-Campos, Policarpo Sales-Júnior, Hugo Leonardo Duarte, Eneas Ricardo Gomes, Silvia Guatimosim, Catherine Ropert, Ricardo Tostes Gazzinelli, Jader Santos Cruz
Jazyk:	angličtina
Rok vydání:	2013
Předmět:	Chagas disease calcium current action potential potassium current intracellular calcium Trypanosoma cruzi Microbiology QR1-502 Infectious and parasitic diseases RC109-216
Zdroj:	Memorias do Instituto Oswaldo Cruz, Vol 108, Iss 2, Pp 243-245 (2013)
Druh dokumentu:	article
ISSN:	1678-8060 0074-0276
DOI:	10.1590/0074-0276108022013019
Popis:	Chagas disease, which is caused by the parasite Trypanosoma cruzi, is an important cause of heart failure. We investigated modifications in the cellular electrophysiological and calcium-handling characteristics of an infected mouse heart during the chronic phase of the disease. The patch-clamp technique was used to record action potentials (APs) and L-type Ca2+ and transient outward K+ currents. [Ca2+]i changes were determined using confocal microscopy. Infected ventricular cells showed prolonged APs, reduced transient outward K+ and L-type Ca2+ currents and reduced Ca2+ release from the sarcoplasmic reticulum. Thus, the chronic phase of Chagas disease is characterised by cardiomyocyte dysfunction, which could lead to heart failure.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/17a00f86b0b34f8a8442419fde5e15aa Zobrazit plný text záznamu View record in DOAJ