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Background: Young patients with diabetes present with reduced compensatory responses to hypovolemic stress. Less compliant veins could be a contributing factor, since roughly two thirds of the blood volume resides in the venous system as a blood reservoir, adjusting proper venous inflow to the heart. The aim of the study was to measure venous compliance as well as lower limb blood pooling during hypovolemic stress, and to correlate them to indices of diabetes severity and glucose control.Methods: Fifteen young women with type 1 diabetes (DW) and eighteen healthy age-matched women (C) were subjected to lower body negative pressure (11-44 mmHg), creating hypovolemic stress. Lowe limb blood pooling was measured with strain-gauge technique and venous compliance calculated as the relationship between delta V/delta P.Results: DW presented reduced blood pooling (e.g. blood pooling during LBNP of 44 mmHg, DW, 1.69±0.10; C, 2.10±0.08, P = 0.003). Calculated venous compliance was also reduced in DW (e.g. compliance at 20 mmHg, DW, 0.046±0.003; C, 0.059±0.002, P = 0.002). A progressive reduction in both venous compliance (P |
