| Autor: |
Amir Ali Rahsepar, David A. Bluemke, Mohammadali Habibi, Kiang Liu, Nadine Kawel‐Boehm, Bharath Ambale‐Venkatesh, Veronica R. S. Fernandes, Boaz D. Rosen, Joao A. C. Lima, James C. Carr |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 8 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2047-9980 |
| DOI: |
10.1161/JAHA.120.019243 |
| Popis: |
Background NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide) is widely used to diagnose and manage patients with heart failure. We aimed to investigate associations between NT‐proBNP levels and development of global and regional myocardial impairment, dyssynchrony, and risk of developing myocardial scar over time. Methods and Results We included 2416 adults (45–84 years) without baseline clinical cardiovascular disease from MESA (Multi‐Ethnic Study of Atherosclerosis). NT‐proBNP was assessed at baseline (2000–2002). Cardiac magnetic resonance–measured left ventricular parameters were assessed at baseline and year 10 (2010–2012). Tagged cardiac magnetic resonance and myocardial dyssynchrony were assessed. We used linear and logistic regression models to study the relationships between quartiles of NT‐proBNP levels and outcome variables. Left ventricular parameters decreased over time. After 10‐year follow‐up and adjusting for cardiovascular disease risk factors, people in the highest quartile had significantly greater decline in left ventricular ejection fraction (−1.60%; 95% CI, −2.26 to −0.94; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Plný text