| Autor: |
Atiah H. Almalki, Hashem O. Alsaab, Walaa F. Alsanie, Ahmed Gaber, Turki Alkhalifa, Ahmad Almalki, Omar Alzahrani, Ana Maria Gregio Hardy, Qasim Alhadidi, Zahoor A. Shah, Yusuf S. Althobaiti |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Healthcare, Vol 9, Iss 4, p 376 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2227-9032 |
| DOI: |
10.3390/healthcare9040376 |
| Popis: |
Substance-use disorder is globally prevalent and responsible for numerous social and medical problems. Pregabalin (Lyrica), typically used to treat diabetic neuropathy, has recently emerged as a drug of abuse. Drug abuse is associated with several neuronal changes, including the downregulation of glutamate transporters such as glutamate transporter 1 and cystine/glutamate antiporter. We investigated the effects of N-acetylcysteine, a glutamate transporter 1 and xCT upregulator, on pregabalin addiction using a conditioned place preference paradigm. Pregabalin (60 mg/kg) was found to induce conditioned place preference when compared to a vehicle. A 100 mg/kg dose of N-acetylcysteine was found to block pregabalin-seeking behaviors. These results support previous findings showing that glutamate transporters play an important role in pregabalin-induced seeking behaviors. N-acetylcysteine may represent a beneficial agent in preventing the abuse potential of pregabalin. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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