Treatment response according to small airway phenotypes: a real-life observational study
| Autor: | Katharina Marth, Monica Spinola, Judith Kisiel, Christian Woergetter, Milos Petrovic, Wolfgang Pohl |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Therapeutic Advances in Respiratory Disease, Vol 10 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1753-4658 1753-4666 17534658 |
| DOI: | 10.1177/1753465816642635 |
| Popis: | Objective: Scant clinical data are available on the effects of current treatments for asthma on different subgroups of patients with this disease. We conducted a prospective, noninterventional, multicenter real-life study in adult patients with persistent asthma, and we specifically analyzed the effects of treatment with extrafine beclometasone dipropionate/formoterol (BDP/F) in asthma patients categorized by phenotypes related to small airways (i.e. smoking habits, disease duration, and air trapping). Methods: Patients received BDP/F as a fixed combination (100/6 μg), administered in 1–2 inhalations twice daily over a period of 12 weeks. Peak expiratory flow (PEF), forced expiratory volume in 1 second (FEV 1 ), forced vital capacity (FVC), number of asthma attacks, asthma control, and severity of asthma symptoms were evaluated in the overall population and in different subgroups at three different time points. Results: Overall, 213 patients were enrolled. In the overall population the treatment resulted in a significant increase in the proportion of well controlled patients (from 6.1% to 66.3%; p |
| Databáze: | Directory of Open Access Journals |
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