Review Paper: Tau Pathology of Alzheimer Disease: Possible Role of Sleep Deprivation

Autor:	Nahid Ahmadian, Sajjad Hejazi, Javad Mahmoudi, Mahnaz Talebi
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Neurofilament proteins Tau proteins Amyloid beta-peptides Amyloid beta-protein precursor Alzheimer's disease Sleep disorder Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Zdroj:	Basic and Clinical Neuroscience, Vol 9, Iss 5, Pp 307-316 (2018)
Druh dokumentu:	article
ISSN:	2008-126X 2228-7442
Popis:	Sleep deprivation is a common complaint in modern societies. Insufficient sleep has increased the risk of catching neurodegenerative diseases such as Alzheimer Several studies have indicated that restricted sleep increases the level of deposition of β-amyloid and formation of neurofibrillary tangles, the major brain microstructural hallmarks for Alzheimer disease. The mechanisms by which sleep deprivation affects the pathology of Alzheimer disease has not yet been fully and definitively identified. However, risk factors like apolipoprotein E risk alleles, kinases and phosphatases dysregulation, reactive oxygen species, endoplasmic reticulum damages, glymphatic system dysfunctions and orexinergic system inefficacy have been identified as the most important factors which mediates between the two conditions. In this review, these factors are briefly discussed.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/1747d46124f34222bcf7cbe00b58be81 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF