Lipopolysaccharide effects on activation and apoptosis of primordial ovarian follicles in heifers

Autor: A.S. Maffi, J.A. Alvarado. Rincón, A.A. Barbosa, M.A. Weiller, R.G. Mondadori, B.G. Gasperin, M.T. Rovani, L.A.X. Cruz, K.C. Freitas, A. Schneider, M.N. Corrêa, J.O. Feijó, F.A.B. Del Pino, V.R. Rabassa, L. Marins, C.C. Brauner
Jazyk: English<br />Portuguese
Rok vydání: 2023
Předmět:
Zdroj: Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Vol 75, Iss 3, Pp 381-390 (2023)
Druh dokumentu: article
ISSN: 1678-4162
DOI: 10.1590/1678-4162-12848
Popis: ABSTRACT The objective of the present study was to evaluate the effect of lipopolysaccharide (LPS) administration on activation and apoptosis of primordial follicles. There was no difference in the total number of follicles as well as in the different types of follicles. Furthermore, the LPS challenge didn’t modulate the expression of genes related with ovarian reserve (HAM), oocyte survival (Survivin), activation rate (Pten, KIT, KITL1, KITL2, AKT1, SIRT1), and follicular abnormalities. Therefore, the LPS exposure with 24h interval had no effect on activation rate and primordial follicles abnormalities, and also had no effect on expression of anti-apoptotic genes and genes related with ovarian reserve, oocyte survival, activation rate, and primordial follicles abnormalities.
Databáze: Directory of Open Access Journals