Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice
| Autor: | Yu Takagi, Laurence Tudor Hunt, Mark W Woolrich, Timothy EJ Behrens, Miriam C Klein-Flügge |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | eLife, Vol 10 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2050-084X 60414901 |
| DOI: | 10.7554/eLife.60988 |
| Popis: | Choices rely on a transformation of sensory inputs into motor responses. Using invasive single neuron recordings, the evolution of a choice process has been tracked by projecting population neural responses into state spaces. Here, we develop an approach that allows us to recover similar trajectories on a millisecond timescale in non-invasive human recordings. We selectively suppress activity related to three task-axes, relevant and irrelevant sensory inputs and response direction, in magnetoencephalography data acquired during context-dependent choices. Recordings from premotor cortex show a progression from processing sensory input to processing the response. In contrast to previous macaque recordings, information related to choice-irrelevant features is represented more weakly than choice-relevant sensory information. To test whether this mechanistic difference between species is caused by extensive over-training common in non-human primate studies, we trained humans on >20,000 trials of the task. Choice-irrelevant features were still weaker than relevant features in premotor cortex after over-training. |
| Databáze: | Directory of Open Access Journals |
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