Toxicity to sea urchin egg development of the quinone fraction obtained from Auxemma oncocalyx
| Autor: | Costa-Lotufo L.V., Ferreira M.A.D., Lemos T.L.G., Pessoa O.D.L., Viana G.S.B., Cunha G.M.A. |
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| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: | |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 35, Iss 8, Pp 927-930 (2002) |
| Druh dokumentu: | article |
| ISSN: | 0100-879X 0034-7310 |
| Popis: | Auxemma oncocalyx Taub. belongs to the Boraginaceae family and is native to the Brazilian northeast where it is known as "pau-branco". We investigated the ability of the water soluble fraction isolated from the heartwood of A. oncocalyx to inhibit sea urchin egg development. This fraction contains about 80% oncocalyxone A (quinone fraction), a compound known to possess strong cytotoxic and antitumor activities. In fact, the quinone fraction inhibited cleavage in a dose-dependent manner [IC50 of 18.4 (12.4-27.2) µg/ml, N = 6], and destroyed the embryos in the blastula stage [IC50 of 16.2 (13.7-19.2) µg/ml, N = 6]. We suggest that this activity is due to the presence of oncocalyxone A. In fact, these quinones present in A. oncocalyx extract have strong toxicity related to their antimitotic activity. |
| Databáze: | Directory of Open Access Journals |
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