Rabies Virus-Neutralizing Antibodies in Free-Ranging Invasive Wild Boars (Sus scrofa) from Brazil

Autor: Patricia Parreira Perin, Talita Turmina, Carmen Andrea Arias-Pacheco, Jonathan Silvestre Gomes, Lívia de Oliveira Andrade, Natália de Oliveira Zolla, Talita Oliveira Mendonça, Wilson Junior Oliveira, Willian de Oliveira Fahl, Karin Correa Scheffer, Rene dos Santos Cunha Neto, Maria Eduarda Rodrigues Chierato, Enio Mori, Artur Luiz de Almeida Felicio, Guilherme Shin Iwamoto Haga, Maria Carolina Guido, Luiz Henrique Barrochelo, Affonso dos Santos Marcos, Estevam Guilherme Lux Hoppe
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Pathogens, Vol 13, Iss 4, p 303 (2024)
Druh dokumentu: article
ISSN: 2076-0817
DOI: 10.3390/pathogens13040303
Popis: Rabies, one of the most lethal global zoonoses, affects all mammals. It remains circulating worldwide in sylvatic cycles through terrestrial and airborne reservoirs, and in Brazil, bats are currently the main reservoirs and source of transmission. Wild boars, an important invasive alien species in Brazil, are a proven food source for hematophagous bats and may participate in the Brazilian sylvatic cycle of rabies. We evaluated the presence of this pathogen in hunted wild boars from the São Paulo state using histopathology, the direct fluorescent antibody test (DFA), viral isolation in cell culture (VICC), the rapid fluorescent focus inhibition test (RFFIT), and quantitative reverse transcription polymerase chain reaction (RT-qPCR). The results of histopathological, DFA, VICC, and RT-qPCR analysis were negative for all samples; seven serum samples tested positive in the RFFIT, and titers ranged from 0.13 IU/mL to 0.5 IU/mL. The presence of rabies virus-neutralizing antibodies in the studied wild boars suggests the circulation of the virus in these animals. Educative actions directed at hunters should include information on the prevention of this important zoonosis.
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