The potential of cystatin C as a predictive biomarker in pulmonary hypertension

Autor: Anqi Duan, Zhihua Huang, Zhihui Zhao, Qing Zhao, Qi Jin, Lu Yan, Yi Zhang, Xin Li, Sicheng Zhang, Meixi Hu, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-11 (2023)
Druh dokumentu: article
ISSN: 1471-2466
DOI: 10.1186/s12890-023-02595-1
Popis: Abstract Background Cystatin C is a novel biomarker to identify renal dysfunction and cardiovascular risk. Objective The aim of this study was to investigate the role of cystatin C in non-invasive risk prediction in a large cohort of patients with pre-capillary pulmonary hypertension (PH). Method We retrospectively analyzed pre-capillary PH patients with available cystatin C and hemodynamic data derived from right heart catheterization. Results A total of 398 consecutive patients with confirmed pre-capillary PH were recruited from Fuwai Hospital between November 2020 and November 2021. Over a median duration of 282 days, 72 (18.1%) of these patients experienced clinical worsening. Cystatin C levels significantly correlated with cardiac index (r = -0.286, P
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