Atrial Fibrillation and Dementia: Pathophysiological Mechanisms and Clinical Implications

Autor: Dimitrios Varrias, Tinatin Saralidze, Pawel Borkowski, Sumant Pargaonkar, Michail Spanos, George Bazoukis, Damianos Kokkinidis
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Biomolecules, Vol 14, Iss 4, p 455 (2024)
Druh dokumentu: article
ISSN: 2218-273X
DOI: 10.3390/biom14040455
Popis: Numerous longitudinal studies suggest a strong association between cardiovascular risk factors and cognitive impairment. Individuals with atrial fibrillation are at higher risk of dementia and cognitive dysfunction, as atrial fibrillation increases the risk of cerebral hypoperfusion, inflammation, and stroke. The lack of comprehensive understanding of the observed association and the complex relationship between these two diseases makes it very hard to provide robust guidelines on therapeutic indications. With this review, we attempt to shed some light on how atrial fibrillation is related to dementia, what we know regarding preventive interventions, and how we could move forward in managing those very frequently overlapping conditions.
Databáze: Directory of Open Access Journals
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