Nine months versus 12 months of adjuvant trastuzumab for patients with HER2-positive breast cancer
| Autor: | Ashraf Mahmoud El-Enbaby, Nadia Ahmed Abd El Moneim, Gehan Abd El atti Khedr, Yasmine Mohamed Nagy Elwany |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Korean Journal of Clinical Oncology, Vol 14, Iss 2, Pp 108-115 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1738-8082 2288-4084 |
| DOI: | 10.14216/kjco.18019 |
| Popis: | Purpose This study aimed to compare the results of treatment with adjuvant trastuzumab for 9 months versus 12 months in human epidermal growth factor 2 (HER2)-positive breast cancer patients. The primary endpoint was disease-free survival. Secondary endpoints included cardiac safety, tolerability, and overall survival. Methods The study included 60 non-metastatic HER2-positive breast cancer patients. All study patients underwent surgery, received adjuvant chemotherapy, radiotherapy and hormonal therapy if indicated. Thirty patients were randomized in each group. Group I patients received adjuvant trastuzumab for 12 months, while group II patients received adjuvant trastuzumab for 9 months. Patients were assessed by clinical examination and Echocardiography during treatment. Results After median follow-up of 12 months, 90% of the patients in group I were disease free and 83.3% of patients in group II were disease free (P=0.402). All studied population in both groups I and II were alive at the end of the 1-year follow-up period after the completion of adjuvant trastuzumab treatment thus overall survival is 100%. Conclusion Trastuzumab is tolerable and its side effects are reversible. Nine months of adjuvant trastuzumab treatment is more cost effective than the standard 12 months. |
| Databáze: | Directory of Open Access Journals |
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