In Vitro, Ex Vivo and In Vivo Techniques to Study Neuronal Migration in the Developing Cerebral Cortex

Autor: Roberta Azzarelli, Roberto Oleari, Antonella Lettieri, Valentina Andre', Anna Cariboni
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Brain Sciences, Vol 7, Iss 5, p 48 (2017)
Druh dokumentu: article
ISSN: 2076-3425
DOI: 10.3390/brainsci7050048
Popis: Neuronal migration is a fundamental biological process that underlies proper brain development and neuronal circuit formation. In the developing cerebral cortex, distinct neuronal populations, producing excitatory, inhibitory and modulatory neurotransmitters, are generated in different germinative areas and migrate along various routes to reach their final positions within the cortex. Different technical approaches and experimental models have been adopted to study the mechanisms regulating neuronal migration in the cortex. In this review, we will discuss the most common in vitro, ex vivo and in vivo techniques to visualize and study cortical neuronal migration.
Databáze: Directory of Open Access Journals