Measurement of serum laminin level during the treatment of chronic hepatitis
| Autor: | Parsian H (PhD), Nouri M (PhD), Somi MH (PhD), Rahimipour A (PhD), Qujeq D (PhD), Estakhri R (PhD), Kashifard M (PhD), Agcheli K(MD), Majidi G(MD) |
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| Jazyk: | perština |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | مجله دانشگاه علوم پزشکی گرگان, Vol 12, Iss 1, Pp 48-55 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1562-4765 2008-4080 |
| Popis: | Background and Objective: Noninvasive methods have been proposed as surrogate markers for liver biopsy in recent years. It was shown that serum laminin level increases with the development for liver fibrosis The aim of this work was to determine serum laminin level cutoff point for predicting liver fibrosis, highlighting its diagnostic value and determining the effect of treatment on its level. Materials and Methods: In this case-control study during 2008-09, serum laminin levels in chronic hepatitis patients (n=62) and controls (n=20) before the beginning of the treatment and three times in a 2 month's interval i.e. 2.4 and 6 months after the beginning of the treatment- were compared by ELISA and stages of fibrosis were assessed according to the liver biopsy. Results: Mean serum laminin concentration in patients (91.9±20.9 ng/ml) was greater than the control (46.2±10.2 ng/ml, P |
| Databáze: | Directory of Open Access Journals |
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