A paralog of Pcc1 is the fifth core subunit of the KEOPS tRNA-modifying complex in Archaea

Autor: Marie-Claire Daugeron, Sophia Missoury, Violette Da Cunha, Noureddine Lazar, Bruno Collinet, Herman van Tilbeurgh, Tamara Basta
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-36210-y
Popis: Many eukaryotic and archaeal tRNAs carry a modified adenosine (t6A) that is synthesized by the KEOPS complex, which is composed of four subunits. A fifth subunit (Gon7) is found only in fungi and metazoa. Here the authors show that archaea also possess a fifth subunit, which is structurally and functionally similar to eukaryotic Gon7.
Databáze: Directory of Open Access Journals