A Novel Benzothiazole-Based Fluorescent AIE Probe for the Detection of Hydrogen Peroxide in Living Cells

Autor:	Dezhi Shi, Yulong Yang, Luan Tong, Likang Zhang, Fengqing Yang, Jiali Tao, Mingxia Zhao
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	fluorescence probe AIE probe hydrogen peroxide benzothiazole base derivative Organic chemistry QD241-441
Zdroj:	Molecules, Vol 29, Iss 21, p 5181 (2024)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules29215181
Popis:	A benzothiazole-based derivative aggregation-induced emission (AIE) fluorescent ‘turn-on’ probe named 2-(2-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)phenyl)benzo[d]thiazole (probe BT-BO) was developed and synthesized successfully for detecting hydrogen peroxide (H2O2) in living cells. The synthesis method of probe BT-BO is facile. Probe BT-BO demonstrates a well-resolved emission peak at 604 nm and the ability to prevent the interference of reactive oxygen species (ROS), various metal ions and anion ions, and good sensitivity. Additionally, the probe boasts impressive pH range versatility, a fast response time to H2O2 and low cytotoxicity. Finally, probe BT-BO was applied successfully to image A549 and Hep G2 cells to monitor both exogenous and endogenous H2O2.
Databáze:	Directory of Open Access Journals
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