| Autor: |
Eun-Young Kim, Taek-Jeong Nam, Jeong Hwan Oh |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Journal of Functional Foods, Vol 35, Iss , Pp 474-480 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2017.06.003 |
| Popis: |
Seaweed-derived antioxidative proteins can protect brain against ethanol-induced oxidative stress. This study was to investigate whether Capsosiphon fulvescens crude proteins (Cf-CP) alleviates the impairment in spatial memory by regulating brain-derived neurotrophic factor (BDNF) and endoplasmic reticulum (ER) stress against chronic ethanol exposure. Oral administration of Cf-CP for 14 consecutive days increased mature BDNF (mBDNF) levels and phosphorylation of calcium/calmodulin-dependent protein kinase II in rat dorsal hippocampus. The latency to platform was decreased and an increase in mBDNF was maintained until the withdrawal at 35 days in Cf-CP treatment. In rats treated with ethanol for four weeks, the ethanol-induced impairment in spatial memory was reduced by co-administration of Cf-CP. This treatment prevented the decrease in mBDNF and the increase in both of ER stress response protein, glucose-regulated protein 78, and protein kinase C delta phosphorylation. These findings suggest that Cf-CP administration improve cognitive functions by regulating BDNF-mediated ER stress response in the dorsal hippocampus. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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