A consensus document for the clinical management of invasive fungal diseases in pediatric patients with hematologic cancer and/or undergoing hematopoietic stem cell transplantation in Brazilian medical centers

Autor: Fabianne Carlesse, Liane Esteves Daudt, Adriana Seber, Álvaro Pimenta Dutra, Analy Salles de Azevedo Melo, Belinda Simões, Carla Renata Donato Macedo, Carmem Bonfim, Eliana Benites, Lauro Gregianin, Marjorie Vieira Batista, Marcelo Abramczyk, Vivian Tostes, Henrique Manoel Lederman, Maria Lúcia de Martino Lee, Sandra Loggetto, Cláudio Galvão de Castro Junior, Arnaldo Lopes Colombo
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Brazilian Journal of Infectious Diseases, Vol 23, Iss 6, Pp 395-409 (2019)
Druh dokumentu: article
ISSN: 1413-8670
DOI: 10.1016/j.bjid.2019.09.005
Popis: In the present paper we summarize the suggestions of a multidisciplinary group including experts in pediatric oncology and infectious diseases who reviewed the medical literature to elaborate a consensus document (CD) for the diagnosis and clinical management of invasive fungal diseases (IFDs) in children with hematologic cancer and those who underwent hematopoietic stem-cell transplantation. All major multicenter studies designed to characterize the epidemiology of IFDs in children with cancer, as well as all randomized clinical trials addressing empirical and targeted antifungal therapy were reviewed. In the absence of randomized clinical trials, the best evidence available to support the recommendations were selected. Algorithms for early diagnosis and best clinical management of IFDs are also presented. This document summarizes practical recommendations that will certainly help pediatricians to best treat their patients suffering of invasive fungal diseases. Keywords: Fungal infections, Children, Cancer
Databáze: Directory of Open Access Journals