Elastin peptides in aging and pathological conditions
| Autor: | Baud Stéphanie, Duca Laurent, Bochicchio Brigida, Brassart Bertrand, Belloy Nicolas, Pepe Antonietta, Dauchez Manuel, Martiny Laurent, Debelle Laurent |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Biomolecular Concepts, Vol 4, Iss 1, Pp 65-76 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1868-5021 1868-503X |
| DOI: | 10.1515/bmc-2011-0062 |
| Popis: | Elastin is the protein responsible for the resilience of vertebrate tissue. It is an extremely stable protein deposited during the early stages of life and experiencing almost no renewal. As a consequence, it can be considered that each individual has an elastin capital for life. Despite its extreme stability, elastin can be degraded by several enzymes termed elastases. Elastases are among the most aggressive proteases, and their presence is increased with age. As a consequence, elastin fragmentation resulting in the generation of elastin peptides is one of the hallmarks of aging. This review will examine their nature and further expose our current understanding of the role played by these peptides in aging and their contribution to tissue homeostasis and several pathologies. |
| Databáze: | Directory of Open Access Journals |
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