Production, immunogenicity, stability, and safety of a vaccine against Clostridium perfringens beta toxins
| Autor: | Mohamed J. Saadh, Issam J. Sa'adeh, Moeen F. Dababneh, Ammar M. Almaaytah, Mohammad F. Bayan |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Veterinary World, Vol 13, Iss 8, Pp 1517-1523 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1517-1523 0972-8988 2231-0916 |
| DOI: | 10.14202/vetworld.2020.1517-1523 |
| Popis: | Background and Aim: The beta toxin is causing the most severe Clostridium perfringens-related diseases. This work was dedicated to developing a vaccine against beta toxin using C. perfringens type C (NCTC 3180). Materials and Methods: The crude toxoid harvest contained 710 limits of flocculation (Lf)/mL. The vaccine was formulated. Each 1 mL of the final vaccine product contained at least 50 Lf/mL of beta toxoids, 0.2 mL 3% aluminum hydroxide gel (equivalent to 5.18 mg of aluminum), 0.05). Conclusion: The research showed a procedure for the manufacturing process of the vaccine against C. perfringens beta toxins with a feasible quantity and the vaccine described here showed to be effective in eliciting levels of neutralizing antibodies higher than required by international standards. In addition, The vaccine was stable up to 30 months. Thus, it may represent an effective and safe for preventing C. perfringens-related diseases in rabbits and cattle, although further studies to prove its efficacy in the field on other farm animals are still needed. |
| Databáze: | Directory of Open Access Journals |
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