Immunogenic cell stress and injury versus immunogenic cell death: implications for improving cancer treatment with immune checkpoint blockade

Autor:	Ganapathy Sriram, Tiffany R. Emmons, Lauren E. Milling, Darrell J. Irvine, Michael B. Yaffe
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	immune checkpoint blockade dna damage immunogenic cell stress immunogenic cell injury tumor immunotherapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular & Cellular Oncology, Vol 9, Iss 1 (2022)
Druh dokumentu:	article
ISSN:	2372-3556 23723556
DOI:	10.1080/23723556.2022.2039038
Popis:	Inducing immunogenic tumor cell death to stimulate the response to immune checkpoint blockade has not yet been effectively translated into clinical practice. We recently discovered that stressed/injured but still viable tumor cells are critical for T-cell priming and substantially improve responses to systemic anti-PD1/CTLA4. Therapeutic tumor cell injury, rather than complete killing, in the tumor microenvironment may enhance efficacy of immunotherapy in various cancers.
Databáze:	Directory of Open Access Journals
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