Endolysosomal Mesoporous Silica Nanoparticle Trafficking along Microtubular Highways

Autor:	Achraf Noureddine, Michael L. Paffett, Stefan Franco, Alfonso E. Chan, Sandeep Pallikkuth, Keith Lidke, Rita E. Serda
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	cytokinesis microtubules super-resolution microscopy scanning electron microscopy tunneling nanotube mitotic nanotube Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceutics, Vol 14, Iss 1, p 56 (2021)
Druh dokumentu:	article
ISSN:	1999-4923
DOI:	10.3390/pharmaceutics14010056
Popis:	This study examines intra- and intercellular trafficking of mesoporous silica nanoparticles along microtubular highways, with an emphasis on intercellular bridges connecting interphase and telophase cells. The study of nanoparticle trafficking within and between cells during all phases of the cell cycle is relevant to payload destination and dilution, and impacts delivery of therapeutic or diagnostic agents. Super-resolution stochastic optical reconstruction and sub-airy unit image acquisition, the latter combined with Huygens deconvolution microscopy, enable single nanoparticle and microtubule resolution. Combined structural and functional data provide enhanced details on biological processes, with an example of mitotic inheritance during cancer cell trivision.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/e16b2579b3594af48cb037b483fcbf3b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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