Molecular analysis of translocations associated with Ewing sarcoma: case report
| Autor: | Leonardo R. Soares, Hugo A. Bayeh, Izabela Cristina Albuquerque, Marise A. R. Moreira, Miguel A. C. Coutinho, Debora F. Rodrigues, Paula O. C. Queiroz, Ruffo Freitas-Junior |
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| Jazyk: | angličtina |
| Předmět: | |
| Zdroj: | Jornal Brasileiro de Patologia e Medicina Laboratorial |
| Druh dokumentu: | article |
| ISSN: | 1678-4774 1676-2444 |
| DOI: | 10.5935/1676-2444.20190020 |
| Popis: | ABSTRACT We report the case of a 25-year-old female patient having a large lesion in the right breast. The core biopsy revealed a high-grade fusocellular neoplasm. Immunostains show no evidence of a specific line of differentiation. The patient underwent radical surgery and adjuvant treatment. Due to the immunohistochemical profile and the rosette arrangement in fusocellular injury, a molecular evaluation of translocations associated to the Ewing sarcoma (ES) was made. However, translocations commonly associated with this disease [t(11;22)(q24;q12)] were not observed. The present report can contribute to the diagnostic investigation of similar cases and to the pre-test orientation of the molecular evaluation. |
| Databáze: | Directory of Open Access Journals |
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