Hair Cell Protection from Ototoxic Drugs

Autor:	Peng Wu, Xianmin Wu, Chunhong Zhang, Xiaoyun Chen, Yideng Huang, He Li
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Zdroj:	Neural Plasticity, Vol 2021 (2021)
Druh dokumentu:	article
ISSN:	2090-5904 1687-5443
DOI:	10.1155/2021/4909237
Popis:	Hearing loss is often caused by death of sensory hair cells (HCs) in the inner ear. HCs are vulnerable to some ototoxic drugs, such as aminoglycosides(AGs) and the cisplatin.The most predominant form of drug-induced cell death is apoptosis. Many efforts have been made to protect HCs from cell death after ototoxic drug exposure. These mechanisms and potential targets of HCs protection will be discussed in this review.And we also propose further investigation in the field of HCs necrosis and regeneration, as well as future clinical utilization.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/16af004f3db34f088551cd93a1a2e65a Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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