Correlations between class I glucose transporter expression patterns and clinical outcomes in non‐small cell lung cancer

Autor: Yoko Nakanishi, Momoko Iwai, Yukari Hirotani, Ren Kato, Tomoyuki Tanino, Haruna Nishimaki‐watanabe, Fumi Nozaki, Sumie Ohni, Xiaoyan Tang, Shinobu Masuda, Kayoko Sasaki‐fukatsu
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Thoracic Cancer, Vol 14, Iss 27, Pp 2761-2769 (2023)
Druh dokumentu: article
ISSN: 1759-7714
1759-7706
DOI: 10.1111/1759-7714.15060
Popis: Abstract Background Glucose transporters (GLUTs) are highly expressed in various cancers. However, the implications of these variable expression patterns are unclear. This study aimed to clarify the correlation between class I GLUT expression patterns and clinical outcomes in non‐small cell lung cancer (NSCLC), including their potential role in inflammatory signaling. Methods Biopsy tissues from 132 patients with NSCLC (92 adenocarcinomas [ADC] and 40 squamous cell carcinomas [SQCC]) were analyzed. mRNA expression levels of class I GLUTs (solute carrier 2A [SLC2A]1, SLC2A2, SLC2A3, and SLC2A4) and inflammation‐related molecules (toll‐like receptors TLR4, RelA/p65, and interleukins IL8 and IL6) were measured. Cellular localization of GLUT3 and GLUT4 was investigated using immunofluorescence. Results Single, combined, and negative GLUT (SLC2A) expression were observed in 27/92 (29.3%), 27/92 (29.3%), and 38/92 (41.3%, p
Databáze: Directory of Open Access Journals
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