Leukocytoclastic Vasculitis as a Complication of Recombinant Granulocyte Colony-Stimulating Factor Therapy in a Heart Transplant Patient

Autor:	Giovanbattista Ippoliti, Marco Paulli, Marco Lucioni, Marinella Lauriola, Andrea Maria D'Armini
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Surgery RD1-811
Zdroj:	Case Reports in Transplantation, Vol 2014 (2014)
Druh dokumentu:	article
ISSN:	2090-6943 2090-6951
DOI:	10.1155/2014/160407
Popis:	Recombinant granulocyte colony-stimulating factor (rG-CSF) is a myeloid growth factor that is widely used in haematology to recover neutropenia secondary to myelosuppressive chemotherapy. Leukocytoclastic vasculitis is an acknowledged side effect of the above therapy. Its pathogenesis involves many mechanisms that collectively induce an increase in neutrophil function and a subsequent release of cytokines. Here, we report a case of leukocytoclastic vasculitis proven by skin biopsy, following the use of rG-CSF in a heart transplant patient with leukopenia secondary to immunosuppressive therapy.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/16ad76e5970b4aa3bfc49074576c64a7 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF