| Autor: |
Zeinab Asgarian, Lorenza Magno, Niki Ktena, Kenneth D. Harris, Nicoletta Kessaris |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Stem Cell Reports, Vol 13, Iss 5, Pp 793-802 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2213-6711 |
| DOI: |
10.1016/j.stemcr.2019.09.008 |
| Popis: |
Summary: Oriens lacunosum-moleculare (O-LM) interneurons constitute 40% of hippocampal interneurons expressing Somatostatin (SST). Recent evidence has indicated a dual origin for these cells in the medial and caudal ganglionic eminences (MGE and CGE), with expression of Htr3a as a distinguishing factor. This is strikingly different from cortical SST interneurons that have a single origin within the MGE/preoptic area (POA). We reassessed the origin of hippocampal SST interneurons using a range of genetic lineage-tracing mice combined with single-cell transcriptomic analysis. We find a common origin for all hippocampal SST interneurons in NKX2-1-expressing progenitors of the telencephalic neuroepithelium and an MGE/POA-like transcriptomic signature for all SST clusters. This suggests that functional heterogeneity within the SST CA1 population cannot be attributed to a differential MGE/CGE genetic origin. : In this article, Kessaris and colleagues combine genetic lineage tracing and single-cell transcriptomic analysis to identify the embryonic origin of hippocampal CA1 Somatostatin interneurons. They report a common origin in the medial ganglionic eminence/preoptic area from neuroepithelial precursors expressing NKX2-1. Keywords: Somatostatin, hippocampus, O-LM, fate-mapping, embryonic origin, single-cell sequencing, interneurons |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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