Autor: |
Chutima Chanprasert, Nutchanawan Promnakhon, Nontaphat Thongsin, Siriwal Suwanpitak, Nattachet Plengvidhya, Pa-thai Yenchitsommanus, Prapaporn Jungtrakoon Thamtarana, Methichit Wattanapanitch |
Jazyk: |
angličtina |
Rok vydání: |
2022 |
Předmět: |
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Zdroj: |
Stem Cell Research, Vol 60, Iss , Pp 102715- (2022) |
Druh dokumentu: |
article |
ISSN: |
1873-5061 |
DOI: |
10.1016/j.scr.2022.102715 |
Popis: |
A heterozygous mutation (c.T1424C: p.L475P) in ZYG11A completely segregating with hyperglycemia in a Thai family with familial diabetes of the adulthood has been reported as a cause of cell cycle arrest in 1.1B4 cell line. This mutation is a suggestive cause of failure in adaptive beta-cell expansion which, thereby, contributes to the development of diabetes in the family. Here, an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMCs) of an affected family member carrying the mutation was generated using Sendai viral reprogramming. The established iPSC line is characterized and confirmed for pluripotency and chromosomal integrity. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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