Autophagic dysfunction of β cell dysfunction in type 2 diabetes, a double-edged sword

Autor:	Ding Yao, Yang GangYi, Wu QiNan
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Apoptosis Autophagic dysfunction Insulin resistance Islet beta cell dysfunction Type 2 diabetes mellitus Medicine (General) R5-920 Genetics QH426-470
Zdroj:	Genes and Diseases, Vol 8, Iss 4, Pp 438-447 (2021)
Druh dokumentu:	article
ISSN:	2352-3042 43778372
DOI:	10.1016/j.gendis.2020.03.003
Popis:	Diabetes is an age-related disease, most of which is type 2 diabetes, and islet β cell dysfunction and insulin resistance are the main mechanisms of type 2 diabetes. Recent studies have revealed that autophagy plays an important role in maintaining the structure and function of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative stress. In this review, we discussed the positive and negative effects of autophagy and its dysfunction on type 2 diabetes mellitus, which is the so-called double-edged sword, analysed its possible mechanism, and identified possible research hot spots.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/1695196ebcdf43778372d10e35548354 Zobrazit plný text záznamu View record in DOAJ