| Autor: |
Ana Patricia Duarte-Jurado, Yareth Gopar-Cuevas, Odila Saucedo-Cardenas, Maria de Jesus Loera-Arias, Roberto Montes-de-Oca-Luna, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Antioxidants, Vol 10, Iss 3, p 453 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2076-3921 |
| DOI: |
10.3390/antiox10030453 |
| Popis: |
Oxidative stress is considered one of the pathological mechanisms that cause Parkinson’s disease (PD), which has led to the investigation of several antioxidants molecules as a potential therapeutic treatment against the disease. Although preclinical studies have demonstrated the efficacy of these compounds to maintain neuronal survival and activity in PD models, these results have not been reflected in clinical trials, antioxidants have not been able to act as disease modifiers in terms of clinical symptoms. Translational medicine currently faces the challenge of redesigning clinical trials to standardize criteria when testing molecules to reduce responses’ variability. Herein, we discuss current challenges and opportunities regarding several non-enzymatic antioxidants’ therapeutic molecules for PD patients’ potential treatment. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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