| Autor: |
Maria-Sophie Brueckle, Elizabeth T. Thomas, Svenja E. Seide, Maximilian Pilz, Ana Isabel Gonzalez-Gonzalez, Truc Sophia Nguyen, Sebastian Harder, Paul P. Glasziou, Ferdinand M. Gerlach, Christiane Muth |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Systematic Reviews, Vol 9, Iss 1, Pp 1-8 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2046-4053 |
| DOI: |
10.1186/s13643-020-01296-8 |
| Popis: |
Abstract Background Unwanted anticholinergic effects are both underestimated and frequently overlooked. Failure to identify adverse drug reactions (ADRs) can lead to prescribing cascades and the unnecessary use of over-the-counter products. The objective of this systematic review and meta-analysis is to explore and quantify the frequency and severity of ADRs associated with amitriptyline vs. placebo in randomized controlled trials (RCTs) involving adults with any indication, as well as healthy individuals. Methods A systematic search in six electronic databases, forward/backward searches, manual searches, and searches for Food and Drug Administration (FDA) and European Medicines Agency (EMA) approval studies, will be performed. Placebo-controlled RCTs evaluating amitriptyline in any dosage, regardless of indication and without restrictions on the time and language of publication, will be included, as will healthy individuals. Studies of topical amitriptyline, combination therapies, or including |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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