Microfluidic Organ-on-a-Chip Models of Human IntestineSummary

Autor: Amir Bein, Woojung Shin, Sasan Jalili-Firoozinezhad, Min Hee Park, Alexandra Sontheimer-Phelps, Alessio Tovaglieri, Angeliki Chalkiadaki, Hyun Jung Kim, Donald E. Ingber
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 659-668 (2018)
Druh dokumentu: article
ISSN: 2352-345X
DOI: 10.1016/j.jcmgh.2017.12.010
Popis: Microfluidic organ-on-a-chip models of human intestine have been developed and used to study intestinal physiology and pathophysiology. In this article, we review this field and describe how microfluidic Intestine Chips offer new capabilities not possible with conventional culture systems or organoid cultures, including the ability to analyze contributions of individual cellular, chemical, and physical control parameters one-at-a-time; to coculture human intestinal cells with commensal microbiome for extended times; and to create human-relevant disease models. We also discuss potential future applications of human Intestine Chips, including how they might be used for drug development and personalized medicine. Keywords: Organs-on-Chips, Gut-on-a-Chip, Intestine-on-a-Chip, Microfluidic
Databáze: Directory of Open Access Journals