Blockade of Cd40-Cd154 Interferes with Human T cell Engraftment in Scid Mice
| Autor: | Teresa M. Foy, Melissa Mcilraith, Sally R. Masters, Jonathan J. Dunn, Aldo A. Rossini, Leonard D. Shultz, Ruth Ann M. Hesselton, Eric J. Wagar, Peter E. Lipsky, Randolph J. Noelle, Dale L. Greiner |
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| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: | |
| Zdroj: | Cell Transplantation, Vol 7 (1998) |
| Druh dokumentu: | article |
| ISSN: | 0963-6897 1555-3892 09636897 |
| DOI: | 10.1177/096368979800700105 |
| Popis: | Antibodies to the ligand for CD40 (CD154) have been shown to exert profound effects on the development of cell-mediated immune responses in mice. The present study shows that an antibody to human CD154 (hCD40L) inhibits in vivo Tetanus toxoid (TT) specific secondary antibody responses in hu-PBL-scid mice, as well as the expansion of xenoreactive human T cells in the scid mice. A possible cause for the reduced expansion of xenoreactive, human T cells, was the decreased expression of murine B7.1 and B7.2 caused by the administration of anti-hCD40L. Therefore, it may be that defective maturation of murine antigen-presenting cells impeded the priming and expansion of human xenoreactive T cells. |
| Databáze: | Directory of Open Access Journals |
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