| Autor: |
Natsuo Tomita, Hiromichi Ishiyama, Chiyoko Makita, Yukihiko Ohshima, Aiko Nagai, Fumiya Baba, Mayu Kuno, Shinya Otsuka, Takuhito Kondo, Chikao Sugie, Tatsuya Kawai, Taiki Takaoka, Dai Okazaki, Akira Torii, Masanari Niwa, Nozomi Kita, Seiya Takano, Shogo Kawakami, Masayuki Matsuo, Tomoyasu Kumano, Makoto Ito, Sou Adachi, Souichiro Abe, Takayuki Murao, Akio Hiwatashi |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
BMC Cancer, Vol 22, Iss 1, Pp 1-8 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2407 |
| DOI: |
10.1186/s12885-022-10371-3 |
| Popis: |
Abstract Background Radiobiological daily changes within tumors are considered to be quite different between stereotactic radiotherapy (SRT) (e.g., 50 Gy in 4 fractions) and conventional radiotherapy (e.g., 60 Gy in 30 fractions). We aim to assess the optimal interval of irradiation in SRT and compare outcomes of daily irradiation with irradiation at two- to three-day intervals in SRT for patients with one to five brain metastases (BM). Methods This study is conducted as a multicenter open-label randomized phase II trial. Patients aged 20 or older with one to five BM, less than 3.0 cm diameter, and Karnofsky Performance Status ≥70 are eligible. A total of 70 eligible patients will be enrolled. After stratifying by the number of BMs (1, 2 vs. 3–5) and diameter of the largest tumor ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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