Advances in the establishment and application of experimental models of optic neuritis associated with neuromyelitis optica

Autor: Meng-Yu Han, Zhi-Jun Wang, Ming Jin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Guoji Yanke Zazhi, Vol 21, Iss 1, Pp 53-56 (2021)
Druh dokumentu: article
ISSN: 1672-5123
DOI: 10.3980/j.issn.1672-5123.2021.1.10
Popis: Neuromyelitis optica(NMO)is an inflammatory central nervous system(CNS)astrocytic disease with high incidence, neuro-ophthalmic intercross, and humoral immune-dominated in Asian population. It has attracted much attention due to its high pathogenicity, high risk of recurrence, and poor prognosis. It is difficult for patients with NMO-associated optic neuritis(NMO-ON)to benefit from routine treatment, and they are often left with different degrees of optic nerve atrophy. One limitation of the study of NMO-ON is the deficiency of the experimental model. Therefore, the progress and application of NMO and NMO-ON experimental model are reviewed in this paper, aiming to explore the pathological mechanism and possible treatment of NMO visual impairment.
Databáze: Directory of Open Access Journals