| Autor: |
Alisa D. Kharlamova, Anton S. Abel, Alexei D. Averin, Olga A. Maloshitskaya, Vitaly A. Roznyatovskiy, Evgenii N. Savelyev, Boris S. Orlinson, Ivan A. Novakov, Irina P. Beletskaya |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Molecules, Vol 26, Iss 7, p 1910 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1420-3049 |
| DOI: |
10.3390/molecules26071910 |
| Popis: |
N-heteroaryl substituted adamantane-containing amines are of substantial interest for their perspective antiviral and psychotherapeutic activities. Chlorine atom at alpha-position of N-heterocycles has been substituted by the amino group using convenient nucleophilic substitution reactions with a series of adamantylalkylamines. The prototropic equilibrium in these compounds was studied using NMR spectroscopy. The introduction of the second amino substituent in 4-amino-6-chloropyrimidine, 2-amino-chloropyrazine, and 1-amino-3-chloroisoquinoline was achieved using Pd(0) catalysis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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