Endometrial transcription of microbial molecular patterns receptors in Gyr and F1 Holstein x Gyr postpartum cows

Autor: T.M. Martins, C.S. Muniz, T.A. Paixão, J.R.M. Ruas, R.L. Santos, Á.M. Borges
Jazyk: English<br />Portuguese
Předmět:
Zdroj: Arquivo Brasileiro de Medicina Veterinária e Zootecnia, Vol 69, Iss 4, Pp 835-842
Druh dokumentu: article
ISSN: 1678-4162
DOI: 10.1590/1678-4162-9093
Popis: ABSTRACT Zebu and Holstein x Zebu crossbred have low incidence of uterine infection when compared to Holstein cows. Resistance to uterine infections may be associated with the ability to recognize invading microorganisms. Endometrial transcription of microbial molecular patterns receptors has been investigated in the postpartum period of Holstein cows, but it is completely unknown in Zebu or Holstein x Zebu cows. In this study, 9 Gyr and 12 F1 Holstein x Gyr cows were submitted to endometrial biopsies at the first and seventh days postpartum, with the objective to measure transcription levels of toll-like receptors (TLRs) 1/6, 2, 4, 5, and 9; nucleotide-binding oligomerization domain (NOD)-like receptors 1 and 2; and coreceptors cluster of differentiation 14 (CD14) and myeloid differentiation protein-2 (MD-2). There was a significant (P
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