NT-proBNP as a predictor of death and cardiovascular events in patients with type 2 diabetes

Autor: Marcus Vinicius Bolivar Malachias, Magnus Olof Wijkman, Marcello Casaccia Bertoluci
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Diabetology & Metabolic Syndrome, Vol 14, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 1758-5996
86204327
DOI: 10.1186/s13098-022-00837-6
Popis: Abstract Existing risk prediction scores based on clinical and laboratory variables have been considered inaccurate in patients with Type 2 Diabetes Mellitus (T2DM). Circulating concentrations of natriuretic peptides have been used to aid in the diagnosis and to predict outcomes in heart failure. However, there is a growing body of evidence for the use of natriuretic peptides measurements, mainly N-terminal pro-B-type natriuretic peptide (NT-proBNP), as a tool in risk stratification for individuals with T2DM. Studies have demonstrated the ability of NT-proBNP to improve outcomes prediction when incorporated into multivariate models. More recently, evidence has emerged of the discriminatory power of NT-proBNP, demonstrating, as a single variable, a similar and even superior ability to multivariate risk models for the prediction of death and cardiovascular events in individuals with T2DM. Natriuretic peptides are synthesized and released from the myocardium as a counter-regulatory response to increased cardiac wall stress, sympathetic tone, and vasoconstriction, acting on various systems and affecting different biological processes. In this article, we present a review of the accumulated knowledge about these biomarkers, underscoring the strength of the evidence of their predictive ability for fatal and non-fatal outcomes. It is likely that, by influencing the functioning of many organs, these biomarkers integrate information from different systems. Although not yet recommended by guidelines, measurement of natriuretic peptides, and particularly NT-proBNP, should be strongly considered in the risk stratification of individuals with T2DM.
Databáze: Directory of Open Access Journals
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